Folamet 30cpr 500mg

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Product Description


Food for Special Medical Purposes (AFMS) and is indicated for the dietary management of hyperhomocysteinemia resulting from a genetic deficiency of the enzyme methylen-tetrahydrofolate reductase (MTHFR), also known as a genetic polymorphism of folic acid. L-5-methylfolate is the metabolically active form of folic acid and is able, through transfer of a methyl group, to convert homocysteine back to methionine even in the presence of the genetic deficiency. Vitamins B2, B6, B12, and zinc are enzymatic cofactors that enhance the activity of L-5-methylfolate in controlling Hyperhomocysteinemia.
Levo-5-methylfolate or methylfolate (6S-5-Methyl-THF or MTHF) is the biologically active form of folate, is naturally present in our bodies, and accounts for 98% of plasma folate. Bioavailability studies have shown that methylfolate supplementation is effective in improving both plasma and erythrocyte folate levels. Methylfolate does not need to be biotransformed by either the enzyme dihydrofolate reductase (DHFR) or the enzyme methylen-tetrahydrofolate reductase(MTHFR). Therefore, the bioavailability of Methylfolate is not limited by saturation of these enzymes, and its intake does not result in the presence of unmetabolized forms of folate in the blood. Methylfolate is therefore not affected by functional polymorphisms in the MTHFR and DHFT genes. Methylfolate possesses a lower risk of interaction with DHFR-inhibiting drugs (e.g., methotrexate), and is less likely to mask hematologic symptoms resulting from vitamin B12 deficiency in patients with pernicious anemia. In addition, methylfolate is stable upon exposure to visible light and UV radiation. Therefore, under conditions of sunlight exposure, supplementation with methylfolate ensures a stability of blood folate levels that cannot be provided by other folates. In conclusion, methylfolate is able to correct Hyperhomocysteinemia even in the presence of genetic mutations and enzyme polymorphisms related to folate metabolism.

L-5-calcium methylfolate (vitamin B9), vitamin B2, vitamin B6, vitamin B12, zinc oxide.

Mode of use.
It is recommended to take 1 tablet daily unless otherwise prescribed by a physician.

The product should be used under medical supervision.

Store in a cool, dry place.
Validity with intact packaging: 36 months.

Pack of 30 tablets.
Net weight: 15 g.
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