Description
Sterile solution.
High hygienic strength Tris-EDTA + N-Acetyl Cysteine (NAC) buffer for dogs and cats.
Tris-EDTA (Ethylene Diammin Tetracetic Acid) has bactericidal activity on non-growing bacteria located within the biofilm (Ciofu et al, 2017); in combination with Tromethamine (Tris) it damages bacterial cell walls and increases penetration within bacterial membranes; it is well tolerated and nontoxic; it acts synergistically with chlorhexidine (Guardabassi et al, 2010). Recently, in vitro work has shown that Tris- EDTA is a more than effective support in treating chronic cases of Pseudomonas otitis with the presence of potential biofilm combined with antibiotics (Pye et al, 2014).
NAC is an N-acetylated derivative of the amino acid cysteine; it has mucolytic action, then destroys exopolysaccharide production thereby weakening the EPS matrix. It has recently been used in eight clinical trials as an adjuvant treatment to destroy mature biofilm and prevent its formation and has demonstrated an excellent safety and efficacy profile.
The combination of Tris-EDTA and NAC on the skin and in the ear prior to the application of topical products such as chlorhexidine, antibiotics, and synthetic antimicrobial peptides, thus allows an increase in the permeability of the mature biofilm and, consequently, its disintegration, effectively supporting the overcoming of the problem of resistance to the classical antibacterial therapeutic approach.

Mode of use.
1. Apply pressure to the top of the bottle until the capsule is completely broken.
2. Shake the bottle.
3. Withdraw with the syringe found inside the package the amount to be used according to the Veterinary Doctor's instructions.
In the ear canal: irrigate adequately and massage at the base of the ear.
On the skin: spray until the affected area is completely imbibed.
Repeat treatment as needed or as directed by the veterinary doctor.

Format
120 ml bottle.

Code. PP3310001